Chirurgie générale et thoracique
Recherche et Enseignement

Investigateur :

  • Etude randomisé en phase III évaluant la Chimiothérapie Hyperthermique Intra Péritonéale dans le traitement du cancer de l’ovaire en Récidive (CHIPOR)
  • Essai de phase III multicentrique, randomisé comparant la surveillance simple (standard) à la laparotomie exploratrice plus chimio-hyperthermie intrapéritonéale (CHIP), chez les patients atteints d’un cancer colorectal, traités initialement par chirurgie chimiothérapie adjuvante, et présentant un haut risque de développer une carcinose péritonéale. (PROPHYLOCHIP)
  • Intérêt de la ChimioHyperthermique IntraPéritonéale (CHIP) adjuvante à l’oxaliplatine dans le traitement des cancers gastriques avancés. Etude nationale, randomisé et multicentrique de phase III (GASTRICHIP)
  • Fiabilité de la cœlioscopie dans l’évaluation du PCI (peritoneal cancer index) des carcinoses péritonéales (CP) débutantes d’origine colorectale. Etude observationnelle, transversale.Cohorte prospective, multicentriqueCOELIOCHIP
  • Evaluation de l ’ intérêt de la résection de la tumeur primitive chez les patients présentant un cancer du rectum avec métastases ( ou des lésions a distance ) non résécables . Etude randomisée multicentrique (GRECCAR 8)
  • Assessment of cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy in first or secondary platinum-resistant recurrence of EOC (clinical recurrence or persistent). (HIPOVA-01)
  • Expression de la myostatine musculaire au cours de la cachexie associée au cancer du colon : etude MYOCAC Investigateur principal


RENAPE :

Membre du Réseau National des Tumeurs Malignes Primitives du Péritoine.


BIG-RENAPE :

Base clinico-biologique des carcinoses péritonéales d’origine digestive.



 

Publications internationales :
 

• Accord d’experts français pour la prise en charge des métastases péritonéales de cancers colo-rectaux : Abboud K, André T, Brunel, Ducreux M, Eveno C, Glehen O, Goéré D, Gornet JM, Lefevre J, Mariani P, Pinto A, Quenet F, Sgarbura O, Ychou M, Pocard M. J Visc Surg. 2019.


• Iterative cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: A multi-institutional experience. Alzahrani NA, Valle SJ, Fisher OM, Sugarbaker PH, Yonemura Y, Glehen O, Goere D, Honore C, Brigand C, de Hingh I, Verwaal VJ, Deraco M, Baratti D, Kusamura S, Pocard M, Piso P, Maerz L, Marchal F, Moran B, Levine EA, Dumont F, Pezet D, Abboud K, Kozman MA, Liauw W, Morris DL; Peritoneal Surface Oncology Group International (PSOGI) and Big-RENAPE groups.J Surg Oncol. 2019 Mar


• Well-Differentiated Papillary Mesothelioma of the Peritoneum: A Retrospective Study from the RENAPE Observational Registry. Hettal L, Vignaud JM, Dartigues P, Goere D, Ferron G, Heyd B, Bereder JM, Tuech JJ, Glehen O, de Chaisemartin C, Lherm Y, Villeneuve L, Kepenekian V, Marchal F1; RENAPE Network : Abba J, Abboud K, et al. Ann Surg Oncol. 2019. Recurrence of pseudomyxoma peritonei after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Mercier F, Dagbert F, Pocard M, Goéré D, Quenet F, Wernert R, Dumont F, Brigand C, Passot G, Glehen O; RENAPE Network: Abba J, Abboud K, et al. BJS Open. 2019.


• Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer With Peritoneal Metastases (CYTO-CHIP study): A Propensity Score Analysis . Bonnot PE, Piessen G, Kepenekian V,2, Decullier E, Pocard M, Meunier B, Bereder JM, Abboud K, Marchal F, Quenet F, Goere D, Msika S, Arvieux C, Pirro N, Wernert R, Rat P, Gagnière J17, Lefevre JH, Courvoisier T, Kianmanesh R, Vaudoyer D, Rivoire M, Meeus P, Passot G, Glehen O; FREGAT and BIG-RENAPE Networks. J Clin Oncol. 2019.


• Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendicular and extra-appendicular origin. Delhorme JB, Severac F, Averous G, Glehen O, Passot G, Bakrin N, Marchal F, Pocard M, Lo Dico R, Eveno C, Carrere S, Sgarbura O, Quenet F, Ferron G, Goéré D, Brigand C; French National Network of Peritoneal Surface Malignancies (RENAPE) Abba J, Abboud K.Br J Surg. 2018 Feb 7


• Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter? Passot G, Kim BJ, Glehen O, Mehran RJ, Kopetz SE, Goere D, Overman MJ, Pocard M, Marchal F, Conrad C, Aloia TA, Vauthey JN, Chun YS; BIG-RENAPE Working Group. Abba J, Abboud K, Alyami M, Arvieux C, Averous G, Bakrin N, Balagué G, Barrau V, Ben Rejeb H, Bereder and all. Ann Surg Oncol. 2018 Jan;25(1):179-187


• Peritoneal Carcinomatosis of Urachus Origin Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): An International Registry of 36 Patients. Mercier F, Passot G, Villeneuve L, Levine EA, Yonemura Y, Goéré D, Sugarbaker PH, Marolho C, Bartlett DL, Glehen O; BIG-RENAPE Working Group Abba J, Abboud K, Alyami M, Arvieux C, Averous G, Bakrin N, Balagué G, Barrau V, Ben Rejeb H, Bereder and all.Ann Surg Oncol. 2018 Apr;25(4):1094-1100


• Multicentre study f laparoscopic or open assessment of the peritoneal cancer index (BIG-RENAPE). Passot G, Dumont F, Goéré D, Arvieux C, Rousset P, Regimbeau JM, Elias D, Villeneuve L, Glehen O; BIG-RENAPE Surgery Working Group. Abba J, Abboud K, Carere S, Durand-Fontanier S, Eveno C, Facy O, Gelli M, Gilly FN, Karoui M, Lo Dico R, Ortega-Deballon P, Pocard M, Quenet F, Rat P, Sabbagh C, Sgarbura O, Thibaudeau E, Vaudoyer D, Wernert R. Br J Surg. 2018 May;105(6):663-667.


• Is there an oncological interest in the combination of CRS/HIPEC for peritoneal carcinomatosis of HCC? Results of a multicenter international study. Mehta S, Schwarz L, Spiliotis J, Hsieh MC, Akaishi EH5, Goere D,Sugarbaker PH, Baratti D, Quenet F, Bartlett DL, Villeneuve L, Kepenekian V; PSOGI and BIG-RENAPE Working Groups. Eur J Surg Oncol. 2018 May 28.


• Peritoneal Carcinomatosis of Rare Ovarian Origin Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Multi-Institutional Cohort from PSOGI and BIG-RENAPE. Mercier F, Bakrin N, Bartlett DL, Goere D, Quenet F, Dumont F, Heyd B, Abboud K, Marolho C, Villeneuve L, Glehen O; PSOGI Working Group; BIG-RENAPE Working Group.Ann Surg Oncol. 2018 Jun;25(6):1668-1675.


• Impact of Combination Chemotherapy in Peritoneal Mesothelioma Hyperthermic Intraperitoneal Chemotherapy (HIPEC): The RENAPE Study. Malgras B, , Gayat E, Aoun O, Lo Dico R, Eveno C, Pautrat K, Delhorme JB, Passot G, Marchal F, Sgarbura O, Ferron G, Goéré D, Andre T, Pocard M5; RENAPE Network.: Abba J, Abboud K, et al. Ann Surg Oncol. 2018.


• Cytoreductive surgery and HIPEC improve survival compared to palliative chemotherapy for biliary carcinoma with peritoneal metastasis: A multi-institutional cohort from PSOGI and BIG RENAPE groups. A mblard I, Mercier F, Bartlett DL, Ahrendt SA, Lee KW, Zeh HJ, Levine EA, Baratti D, Deraco M, Piso P, Morris DL, Rau B, Tentes AAK, Tuech JJ, Quenet F, Akaishi E, Pocard M, Yonemura Y, Lorimier G, Delroeux D, Villeneuve L17, Glehen O1, Passot G; PSOGI and BIG RENAPE working groups. Abba J, Abboud K et al. Eur J Surg Oncol. 2018 Sep


• The RENAPE observational registry: rationale and framework of the rare peritoneal tumors French patient registry. Villeneuve L, Passot G, Glehen O, Isaac S, Bibeau F, Rousset P, Gilly FN; RENAPE Network. Collaborators: Abba J, Abboud K, and all Orphanet J Rare Dis. 2017 Feb 17;12(1):37. doi: 10.1186/s13023-017-0571


• Immunohistochemical evaluation of two antibodies against PD-L1 and prognostic significance of PD-L1 expression in epithelioid peritoneal malignant mesothelioma: A RENAPE study Valmary-Degano S, Colpart P, Villeneuve L, Monnien F2, M'Hamdi L, Lang Averous G, Capovilla M, Bibeau F, Laverriere MH, Verriele-Beurrier V, Ben Rejeb H, Dartigues P, Hommell-Fontaine J12, Gilly FN, Isaac S, Mery E; French RENAPE Network :Abba J, Abboud K, and all Eur J Surg Oncol. 2017 May 18.


• Patients with Peritoneal Carcinomatosis from Gastric Cancer Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Is Cure a Possibility? Chia CS, You B, Decullier E, Vaudoyer D, Lorimier G, Abboud K, Bereder JM, Arvieux C, Boschetti G, Glehen O; BIG RENAPE Group.Ann Surg Oncol. 2016 Jun;23(6):1971-9.


• A new internet tool to report peritoneal malignancy extent. PeRitOneal MalIgnancy Stage Evaluation (PROMISE) application. Villeneuve L, Thivolet A, Bakrin N, Mohamed F, Isaac S, Valette PJ, Glehen O, Rousset P; BIG-RENAPE and RENAPE Working Groups. Abba J, Abboud K, and all . Eur J Surg Oncol. 2016 Jun;42(6):877-82


• Diffuse malignant peritoneal mesothelioma: Evaluation of systemic chemotherapy with comprehensive treatment through the RENAPE Database: Multi-Institutional Retrospective Study . Kepenekian V, Elias D, Passot G, Mery E, Goere D, Delroeux D, Quenet F, Ferron G, Pezet D, Guilloit JM, Meeus P, Pocard M, Bereder JM, Abboud K, Arvieux C, Brigand C, Marchal F, Classe JM, Lorimier G, De Chaisemartin C, Guyon F, Mariani P, Ortega-Deballon P, Isaac S, Maurice C, Gilly FN, Glehen O; French Network for Rare Peritoneal Malignancies (RENAPE).Eur J Cancer. 2016 Sep;65:69-79.


• Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis in the Elderly: A Case-Controlled, Multicenter Study . Alyami M, Lundberg P, Kepenekian V, Goéré D, Bereder JM, Msika S, Lorimier G, Quenet F, Ferron G, Thibaudeau E, Abboud K, Lo Dico R, Delroeux D, Brigand C, Arvieux C, Marchal F, Tuech JJ, Guilloit JM, Guyon F, Peyrat P, Pezet D, Ortega-Deballon P, Zinzindohoue F, de Chaisemartin C, Kianmanesh R, Glehen O, Passot G; BIG-RENAPE and RENAPE Working Groups.Ann Surg Oncol. 2016 Dec;23(Suppl 5):737-745.


• Peritoneal Carcinomatosis Treated With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced ovarian carcinoma : Retrospective Analysis of 626 patients From a Multicentric French Study .: Naoual Bakrin, Jean Marc Bereder, Evelyne Decullier, Jean Marc Classe, Simon Msika, Gérard Lorimier, Karine Abboud, Pierre Meeus, Gwenael Ferron, François Quenet and Olivier Glehen ; from the FROGHI (FRench Oncologic and Gynecologic HIPEC) GroupEur J Surg Oncol. 2015 Oct;.


• Professional risks when carrying out cytoreductive surgery for peritoneal malignancy with hyperthermic intraperitoneal chemotherapy (HIPEC): A French multicentric survey . Ferron G, Simon L, Guyon F, Glehen O, Goere D, Elias D, Pocard M, Gladieff L, Bereder JM8, Brigand, Classe JMGuilloit JM, Quenet F, Abboud K, Arvieux C, Bibeau F, De Chaisemartin C, Delroeux D, BIG-RENAPE Working Group. Eur J Surg Oncol. 2015 Oct;41(10):1361-7


• Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for First Relapse of Ovarian Cancer. Classe JM, Glehen O, Decullier E, Bereder JM, Msika S, Lorimier G, Abboud K, Meeus P, Ferron G, Quenet F, Marchal F, Gouy S, Pomel C, Pocard M, Guyon F, Bakrin N; French Oncologic and Gynecologic HIPEC Group.Anticancer Res. 2015 Sep;35(9):4997-5005